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Information für die Wissenschaft Nr. 24 | 15. Juni 2010
Priority Programme 1365 “The Regulatory and Functional Network of Ubiquitin Family Proteins“

2nd Call for Proposals

Ubiquitin (Ub) has classically been associated with protein degradation via the 26S proteasome. However, in the past decade various non-proteolytic functions of Ub have been elucidated. Additionally, the discovery and investigation of Ub family proteins (UbF) proteins, such as SUMO, NEDD8, FAT10 or ISG15, the majority of which do not primarily function as signals for proteasomal degradation, have provided important new insights in our understanding of cellular key processes, such as signal transduction, DNA repair, transcriptional regulation or protein trafficking. The coordinated investigation of the regulatory and functional network of UbF proteins is the major aim of the UbF Priority Programme (SPP). The prospective participants of the UbF network SPP will delineate the interplay and interconnection of UbF pathways as a novel regulatory principle for many important biological processes. The ultimate goal is to provide an integrated view of the UbF network and major aims are:

  • to define the regulatory functions of UbF modifications

  • to identify and characterise novel UbF binding modules

  • to identify the cellular machineries for UbF conjugation and deconjugation

  • to elucidate the regulatory network characterised by the interplay and overlap of functions of different UbF members 

To ensure maximal synergy, the network aims to focus on regulatory functions of – and crosstalk between – UbF proteins. Therefore, typical studies on polyubiquitin-mediated protein degradation by the 26S proteasome are intentionally excluded and cannot be considered. 

Proposals for the second funding period should be submitted on paper (1 copy) and on CD-ROM not later than 27 October2010. Proposals must be written in English, and the title and project summary should also be provided in German. Please submit proposals, marked as “SPP 1365” and addressed to the attention of Dr. Dorette Breitkreuz, to the Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn. Proposals must be prepared according to the guidelines for individual research grants (1.02e).

Further Information

Guidelines for individual research grants can be found at:

Scientific questions can be directed to the coordinator of the Priority Programme:

Questions regarding the DFG applications should be directed to: