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Information for Researchers No. 55 | 30 September 2014
THYROID TRANS ACT – Translation of Thyroid Hormone Actions beyond Classical Concepts (SPP 1629)

The Senate of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) has established a Priority Programme entitled ”THYROID TRANS ACT” (SPP 1629). The programme started in 2012 and is designed to run for six years. Applications are now invited for the second three-year period.

The programme focuses on the central question: What defines healthy and diseased thyroid function?

THYROID TRANS ACT deciphers the actions of thyroid hormones (TH) comprising T4 and T3 and novel, endogenous thyroid hormone derivatives such as T2 and thyronamines (from “T4-T0”). In particular, THYROID TRANS ACT investigates (i) classical and non-classical TH and their transporters, (ii) thyronamines and their receptors, and (iii) the interrelatedness of “T4-T0” in target tissues. The programme aims at unravelling consequences of disturbed TH signalling with the goal to prevent and target TH dependent disease.

In the second funding period THYROID TRANS ACT will include projects covering the following topics:

  • Networking of TH dependent targets in a cell- and organ-specific context
  • Non-classical aspects of TH action
  • Relevance of “T4–T0” function in different phases of life
  • Linking TH action to disease
  • Molecular targeting of TH-related disease

The THYROID TRANS ACT programme will not include projects that focus on

  • classical TH action
  • pathogenesis of thyroid disorders such as autoimmune disease, goiter, or thyroid tumours
  • TH in obesity and oncology

Proposals must be submitted in English no later than February 18th 2015 via the DFG’s electronic submission system “elan” selecting “SPP 1629/2”.

Please follow the guidelines for project submission according to forms 50.05 and 54.01. Proposals by one applicant must not exceed 20 pages. Joint proposals may comprise five additional pages for each additional applicant. If you are using the elan system for the first time, please note that you need to register yourself and your institutional address before being able to submit a proposal. Also, if you are planning to move to a different institution (e.g. with a Temporary Position for Principal Investigators) you need to register the new institutional address beforehand. Please make sure that all applicants of your project (in case there is more than one) start their registration at the latest two weeks before the submission deadline. The registration requests are handled manually by DFG staff.

Please notice the rules for publication lists that have been modified: Beside the general bibliography every proposal should include a list of up to ten publications that relate directly to the project. Further, the number of publications that may be listed in any academic CV has been increased to up to ten as well.

Proposals will be evaluated in the course of a colloquium in Berlin with short talks and poster presentations scheduled for June 2nd 2015.

Further Information

The DFG’s electronic portal “elan” can be found at:

Proposal guidelines and preparation instructions are outlined in DFG forms 50.05 and 54.01, which can be found on the DFG’s website at:

For scientific enquiries concerning the scope of the programme, please contact the Priority Programme’s coordinator:

Further instructions on submitting a proposal are supplied by the DFG:

For scientific matters:

For administrative matters: