Information für die Wissenschaft Nr. 21 | 12. Mai 2014
Priority Programme “Epithelial Intercellular Junctions as Dynamic Hubs to Integrate Forces, Signals and Cell Behaviour” (SPP 1782)
The Senate of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) has established a new Priority Programme entitled “Epithelial Intercellular Junctions as Dynamic Hubs to Integrate Forces, Signals and Cell Behaviour” (SPP 1782). The programme is designed to run for six years, the present call invites proposals for the first three-year funding period.
Epithelia are stable tissues that line organ and body surfaces to provide structural support and serve as barriers against diverse external stressors such as mechanical force, pathogens, toxins, and dehydration. Further, they separate different physiological environments and are instrumental during morphogenesis. These epithelial functions depend to a great extent on the ability of intercellular junctions to sense and integrate mechanical forces and chemical signals. They transmit these into the cell to direct rapid changes in cell architecture and/or transcriptional programming thus directing cellular behaviour.
Understanding how intercellular junctions sense their neighbours, force and chemical signals, how such information at these junctions is integrated to elicit cellular responses at a mechanistic level will be central to comprehend control of tissue morphogenesis, homeostasis and regeneration. Further, elucidating how genetic defects in intercellular junction components by-pass junction-mediated control of epithelial tissue integrity is a prerequisite to understand the basis of multiple disorders including blistering skin disorders, inflammation and cancer.
The primary goal of the Priority Programme is thus to understand how intercellular junctions sense and respond to mechanical and chemical signals from neighbouring cells and how they convert these signals into processes that underlie epithelial morphogenesis, differentiation and pathogenesis. To this end the Priority Programme invites interdisciplinary approaches that bridge the levels of molecules, cells, tissues and model organisms, combining biophysical, biochemical, cell biological and physiological techniques. Projects should aim at the following goals:
- identification of molecules that sense and transmit mechanical force and chemical signals at intercellular junctions, to get insights into downstream signal transmission
- integration of mechanical and chemical signals by adherens junctions and desmosomes to regulate cell behaviour and cell fate
- understanding at a quantitative level how mechanical force is sensed at intercellular junctions and how it is transmitted into chemical signals
- elucidation of the force-dependent crosstalk between intercellular junctions and the cytoskeleton
- advancement of biophysical and imaging methods to analyse force and chemical signal transmission via adhesive junctions in tissues
To foster optimal collaboration between groups, the following projects are explicitly excluded:
- work on cytoskeletal proteins not focussing on their interactions with intercellular junctions
- analysis of cell-matrix junctions except if they address crosstalk between hemidesmosomes and intercellular junctions
- studies on gap and tight junctions except if they investigate potential adhesive functions
- descriptive approaches including non-mechanistic studies on disease conditions or animal models
- identification or characterisation of adhesive junction-related biomarkers
Research proposals for the first three-year funding period are now invited. Deadline for submission is 8 October 2014. All proposals must be written in English and follow the guidelines in DFG form 54.01 (Proposal Preparation Instructions – Project Proposals). Please mention your name, your address, the title of your project and the title of the Priority Programme on the first page of your application. Further relevant information on e.g. eligibility requirements can be found in DFG form 55.05, part B.
Proposals must be submitted via the DFG’s electronic submission system elan, selecting “SPP 1782”. If you are using the elan system for the first time, please note that you need to register yourself and your institutional addresses before being able to submit a proposal. Also, if you are planning to move to a different institution (e.g. with a Temporary Position for Principal Investigators) you need to register the new institutional address beforehand. Please make sure that all applicants of your project (in case there is more than one) start their registration at the latest two weeks before the submission deadline. The registration requests are handled manually by DFG staff.
In addition to submitting your proposal to the DFG, please send an electronic version (pdf format) to the coordinator. The review process will most likely include a colloquium with talks and/or poster presentations tentatively scheduled to take place in Leipzig in December 2014 or January 2015.
The DFG’s electronic portal “elan” can be found at:
Proposal instructions and guidelines can be found at:
For scientific enquiries please contact the coordinator of the Priority Programme:
- Professor Dr. Thomas Magin,
Translationszentrum für Regenerative Medizin,
phone: +49 341 97-39582,
For administrative enquiries please contact:
- Dr. Britta Mädge,
phone: +49 228 885-2453,