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Information für die Wissenschaft Nr. 17 | 10. Mai 2010
DFG-Schwerpunktprogramm SPP 1356: Pluripotency and Cellular Reprogramming

Call for Proposals

In 2007 the DFG established a new Priority Programme (Schwerpunktprogramm, SPP) entitled “Pluripotency and Cellular Reprogramming”. This programme is now opening a call for a second and last funding period (2011–2013).

The research field of pluripotency and cellular reprogramming is one of the most challenging and promising research fields in biomedicine. This is highlighted by the recent progress in direct reprogramming of somatic cells into pluripotent cells. However, the molecular pathways controlling pluripotency and reprogramming remain incompletely understood. A thorough understanding of these mechanisms is essential for the development of effective and rational approaches to induce reprogramming towards the pluripotent state.

The following questions are at the core of the SPP 1356:

  • Which molecular processes are crucial for the establishment and maintenance of natural pluripotency?
  • What defines the exit from pluripotency?
  • What crosstalk and interdependence exist between genotype and epigenotype?
  • What determines the global and local chromatin organisation in pluripotent cells?
  • What are the molecular and epigenetic mechanisms leading to induced pluripotency?
  • What is the interrelation of regulatory processes that generate pluripotent cells in mammals versus non-mammals?

Projects should address the analysis of pluripotency at the functional level, the epigenome of pluripotent cells and/or basic mechanisms of pluripotency and reprogramming.

The following topics are not covered by this Priority Programme: developmental patterning and differentiation, organ and tissue regeneration, stem cell therapy, somatic stem cell biology, reproduction biology and tumour biology.

Proposals (in English) should be submitted to the DFG with the keyword “pluripotency” by Monday, 9 September 2010. Please prepare your grant proposal according to the guidelines for individual research grants. It is anticipated that funding of individual projects will be able to commence by spring 2011. Proposals can be funded for a three year period.

Further Information:

Guidelines for individual research grants can be found at:

 Specific information on Priority Programmes is available at:

Contact address for further information:

Coordinator:

  • Prof. Dr. Albrecht Müller, Institut für Medizinische Strahlenkunde und Zellforschung (MSZ) im Zentrum für Experimentelle Molekulare Medizin (ZEMM), Zinklesweg 10, 97078 Würzburg, Germany, Tel. +49 931 201-45848,
    albrecht.mueller@mail.uni-wuerzburg.de

 For information on submitting proposals, contact office:

  • Dr. Tobias Grimm, Deutsche Forschungsgemeinschaft, Lebenswissenschaften 1, 53170 Bonn, Germany, Tel. +49 228 885-2325,
    tobias.grimm@dfg.de

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